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Cholesterol inhibits NFKB1. 2 / 2
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2
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"35 A previous study revealed that chronic cholesterol depletion promoted tumor cell proliferation by inducing NFkB activation.36 Furthermore, hypocholesterolemia was shown to be associated with a poor prognosis in many cancer patients.37,38Previous studies indicated that nutritional intervention could reduce postoperative complications and improve the tolerance of patients to anticancer treatment.39,40 However, the effects of nutritional intervention on the long-term oncological outcomes in patients with cancer-related malnutrition have not been confirmed."
reach
"In our experiments, OX40 translocated into DIM after interaction with OX40L and although we found that the interaction between OX40 and the TRAF2-IKK compartment was independent of DIM, depletion of cholesterol or suppression of synthesis of sphingolipid and cholesterol strongly inhibited OX40 dependent NF-kappaB1 activation."