IndraLab

Statements

UCHL5 decreases the amount of SMAD2. 3 / 3
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"UCHL5 shRNA (# 2, # 3, not # 1, # 4) diminished protein levels of Smad2 and Smad3 (XREF_FIG)."
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"In the present study, we confirmed that the blockade of UCHL5 activity by the DUB inhibitor bAP15 inhibited expression of phospho-Smad2/Smad3 in a concentration-dependent manner and induced apoptosis in ovarian cancer cells."
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"Since bAP15 treatment inhibited UCHL5 expression, negatively regulated Smad2 expression, and activated the ERK signaling pathway, we further determined the angiogenic potential of the supernatant using human umbilical vein endothelial cells (HUVEC)."
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