IndraLab

Statements

BAP1 binds YY1. 16 / 19
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"Instead, association of Yin Yang 1 with BAP1 could be the remnant of an ancient association between Pleohomeotic and Calypso, which would have allowed for the recognition of Polycomb response elements by the Drosophila PR-DUB complex."
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"However, BAP1 can also form complexes with many other proteins, including the tumor suppressor BRCA1, host cell factor-1 (HCF-1), N-acetylglucosamine transferase, the forkhead box transcription factors FOXK1/2, MBD family proteins MBD5/6, transcription factor YY1 and ubiquitin conjugating enzyme UBE20 [XREF_BIBR, XREF_BIBR - XREF_BIBR]."
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"may be important for the growth effects of HCF-1, which are partly mediated by modulation, at E2F responsive promoters, of progression of cells through the G1/S-phase boundary and transcription of gen[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Given BAP1’s crucial role in early placentation xref , it is plausible that BAP1 may interact with YY1 to regulate trophoblast proliferation and invasion, offering a novel avenue for exploring the mechanisms underlying pregnancy disorders."
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"BAP1 interacts with BARD1 (182aeuro " 365), HCF-1 (365aeuro " 385), BRCA1 (596aeuro " 721) and YY1 (642- 686).10,88 Numbers refer to amino acid positions."
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"Thus, targeting the BAP1‐YY1 axis may represent a novel therapeutic approach in PM."
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"– YY1 (Ying Yang 1) transcription factor that binds to a zinc finger domain BAP1 and HCF1."
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"BAP1 also associates with transcription factors, including FOXK1, FOXK2, and Yin Yang1 (YY1), which ensure the recruitment of this DUB to chromatin (133, 142)."
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"93 In addition, the transcriptional repressor protein YY1, which functions as a PcG protein in Drosophila, 99 also interacts with BAP1."
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"Moreover, HCF-1 interacts with the middle region of YY1 encompassing the glycine-lysine-rich domain and is essential for the formation of a ternary complex with YY1 and BAP1 in vivo."
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