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EIF3F deubiquitinates FBXW7. 2 / 2

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"Moreover, we uncover that PHGDH is a novel substrate of GSK3β/FBXW7β and eIF3f could deubiquitinate FBXW7β‐mediated ubiquitination of PHGDH."

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"39 Our study identified PHGDH as a novel substrate of FBXW7β and implies that eIF3f may participate in deubiquitinating FBXW7 targets.Wnt signaling is a pivotal oncogenic pathway in CRC, and targeting this pathway for therapeutic strategy is very appealing."

37544925

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IndraLab

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EIF3F deubiquitinates FBXW7. 2 / 2

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