IndraLab

Statements


OTUB1 decreases the amount of FOXM1. 3 / 5
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"Other experiments confirmed that OTUB1 slowed FOXM1 degradation and reduced the FOXM1 ubiquitination level ( Figs."

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"Nevertheless, the correlations between the kinetics of OTUB1 and FOXM1 expression in the sensitive and resistant MCF-7 cells in response to DNA damaging agents support the notion that OTUB1 restricts the downregulation of FOXM1 expression in response to DNA damage and genotoxic agents."

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"Notably, the amount of FOXM1 protein that was pulled down was remarkably increased by OTUB1 knockdown, demonstrating that more FOXM1 was ubiquitinated under the OTUB1-depleted conditions."