IndraLab

Statements

TBX5 activates SCN5A. 3 / 3
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sparser
"Similar to the other atrial working myocardial genes such as Nppa and Cx40, Scn5a is directly activated by Nkx2–5 and Tbx5, but repressed by Tbx3 [ xref , xref , xref ]."
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reach
"This Scn10a region is a known TBX5-dependent enhancer of Scn5a, and was identified as containing a GWAS SNP associated with altered electrophysiology in humans (van den Boogaard et al., 2014, 2012)."
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eidos
"Recently , it was functionally demonstrated that Tbx5 , a TF belonging to the T-box family , promotes the expression of the SCN5A gene , and thus increased INa in human cardiomyocytes derived from induced pluripotent stem cells ( hiPSC-CM ) [ 13 ] ."
| PMC