IndraLab

Statements

TBX5 activates SCN5A. 4 / 4
| 1 1 2
eidos
"Recently , it was functionally demonstrated that Tbx5 , a TF belonging to the T-box family , promotes the expression of the SCN5A gene , and thus increased INa in human cardiomyocytes derived from induced pluripotent stem cells ( hiPSC-CM ) [ 13 ] ."
| PMC
sparser
"Moreover, the two mutations nullified the synergistic activation of SCN5A by SOX4 and TBX5."
39518344
reach
"This Scn10a region is a known TBX5-dependent enhancer of Scn5a, and was identified as containing a GWAS SNP associated with altered electrophysiology in humans (van den Boogaard et al., 2014, 2012)."
30814119
sparser
"Similar to the other atrial working myocardial genes such as Nppa and Cx40, Scn5a is directly activated by Nkx2–5 and Tbx5, but repressed by Tbx3 [ xref , xref , xref ]."
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