IndraLab

Statements

USP3 activates Neoplasm Invasiveness. 15 / 15
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"USP3 promotes the proliferation, migration and invasion of OS cells."
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"Additionally, we demonstrated that USP3 promoted the proliferation, migration and invasion of OS cells."
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"Additionally, USP3 promotes GC cell migration and invasion by positively regulating the EMT process."
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"Silencing of USP3 attenuates the migration and invasion abilities of GBM cells in vitro and tumor growth in an orthotopic xenograft mouse model."
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"In contrast, overexpression of USP3 promoted cell proliferation, migration, and invasion."
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"52 Overall, USP3 primarily functions as a tumor promoter in GC, driving GC cell proliferation, invasion, migration, and the EMT process.Ubiquitin‐specific protease 3 has also been implicated in esophageal squamous cell carcinoma (ESCC)."
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"Cellular experiments confirmed that high expression of USP3 and Aurora A in ESCC cells promoted malignant cell proliferation and invasion."
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"Through the deubiquitination of the K143 residue of Aurora A, a serine/threonine kinase associated with centrosomes and mitosis, USP3 promotes invasion and metastasis in ESCC cells."
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"As shown in Fig. 6a-c, USP3 overexpression significantly promoted cell migration and invasion compared to empty vector-transfected cells, whereas Dox-induced DNM1L silencing suppressed the capabilities."
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"Functional phenotype analysis demonstrated that the overexpression of USP3 significantly promoted the proliferation, migration, and invasion of OS cells."
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"According to the literature review, USP3 promotes GC cell migration and invasion [20]; SLC7A6 hasn’t been reported in studies related to cancer; IGF2BP1 accelerates GC progression [21]; and TKT facilitates breast cancer metastasis [22]."
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"These results underscore the key role of DNM1L in a USP3-induced enhancement of proliferation, migration, and invasion capacities of GBC cells."
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"Overexpression of USP3 significantly increased OS cell proliferation, migration, and invasion ."
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"It promotes cell proliferation, invasion, migration, DNA damage repair, and glycolysis, potentially via the Wnt/β-catenin signaling pathway.14 Similarly, USP3 promotes cholangiocarcinoma proliferation and invasion through the Wnt/MYC pathway, enhancing tumor cell glycolysis, energy production, and upregulating metabolic target genes such as GLUT1, HK2, PDM2, and LDHA.87 Egfr/Stat3."
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"Overexpression of USP3 significantly increased OS cell proliferation, migration, and invasion."
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