IndraLab

Statements

USP35 activates ESR. 4 / 4
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"USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis."
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"Similar effects have been observed in breast cancer, where USP35 enhances tumorigenesis by stabilizing estrogen receptor α (ERα), leading to increased proliferation and metastasis [37]."
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"Moreover, USP15 and USP35 also mediate ERα protein stability and promote breast cancer tamoxifen resistance in human breast cancer [ 51 , 52 ]."
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"For example, USP35 promotes tumorigenesis in estrogen receptor (ER)-positive breast cancer by stabilizing and activating estrogen receptor α (Erα) to increases Erα transcriptional activity [19]."
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