IndraLab

Statements

YOD1 inhibits TRAF6. 4 / 6
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"Indeed, co-IP experiments using MYC-TRAF6 together with Crimson-p62 and GFP-YOD1 revealed that YOD1 was able to inhibit the association of TRAF6 and p62, while p62 did not alter the binding of YOD1 to TRAF6 (XREF_FIG)."
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"YOD1 antagonizes ubiquitin ligase TRAF6 and p62 dependent interleukin-1 signaling to NF-kappaB."
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"We show that YOD1 competes with p62 for TRAF6 association and abolishes the sequestration of TRAF6 to cytosolic p62 aggregates by a non catalytic mechanism."
28244869
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"Hence, our data define that YOD1 antagonizes TRAF6 and p62 dependent IL-1 signaling to NF-kappaB."
28244869