IndraLab

Statements

BAP1 inhibits miR-31. 3 / 3
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reach
"Xenografts with both miR-31 and BAP1 overexpression exhibited reduced cell mitosis compared to xenografts with miR-31 overexpression, suggesting that BAP1 overexpression could attenuate the pro proliferative effect of miR-31."
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"Finally, the cells transfected with miR-31 and the BAP1 overexpression plasmid exhibited significantly lower proliferation rates compared with the cells transfected with miR-31 and the control plasmid, suggesting that miR-31-resistant BAP1 could rescue the suppression of BAP1 by miR-31 and attenuate the proliferative effect of miR-31."
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"Additionally, BAP1 overexpression attenuated the promotive effect of miR-31 on tumor growth, suggesting that miR-31 might promote tumor growth by silencing BAP1."
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