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CXCL12 activates KCNH2. 7 / 9
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"Current-voltage relationship of outward of peak tail currents had been shown in Fig. 4 C. SDF-1 (100 ng/ml) significantly increased hERG tail currents."
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"Our electrophysiologic results showed that SDF-1 significantly increased hERG tail current, which suggested that SDF-1 enhance functional role of hERG1 K + channels."
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"According to our observations, SDF-1 increased hERG current which could engender an increased malignancy of hERG."
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"It had beenshowed that inhibition of CXCR4 and SDF -1 axis in AML cells led to reduce proliferation and survival,17 andSDF-1 promoted AML-cell proliferation also by regulating the expression of elastase.19 In light ofthe data presented here, it may be possible that SDF-1 promotes AML-cell proliferation also by regulating the hERG1 Kz channel, which we found to beinvolved in regulation of AML-cell proliferation."
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"Berberine may partially inhibit the migration of primary acute myeloid leukemia (AML) cells by reducing the level of SDF-1 protein secreted by bone marrow mesenchymal stem cells in microenvironment and inhibiting HERG1 potassium channel of leukemic cells."
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"16 NO. 3 179 Zheng et al. hERG1 Kz channels mediate positive regulation of SDF-1a-induced proliferationDownloaded by [University of Wisconsin - Madison] at 19:22 12 December 2017Figure 2 The hERG1 Kz blocker impaired leukemic cell proliferation induced by SDF-1a and accumulated cells in the G0/G1 phase."
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"Moreimportantly, SDF-1 enhanced herg1 gene expression ina dose dependent manner."
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