IndraLab

Statements

CXCL12 activates KCNH2. 5 / 7
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"According to our observations, SDF-1 increased hERG current which could engender an increased malignancy of hERG."
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"Berberine may partially inhibit the migration of primary acute myeloid leukemia (AML) cells by reducing the level of SDF-1 protein secreted by bone marrow mesenchymal stem cells in microenvironment and inhibiting HERG1 potassium channel of leukemic cells."
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"Our electrophysiologic results showed that SDF-1 significantly increased hERG tail current, which suggested that SDF-1 enhance functional role of hERG1 K + channels."
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"SDF-1 increased hERG1 K (+) current expressed in oocytes and HEK293T cells transfected with herg-pEGFP."
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"Current-voltage relationship of outward of peak tail currents had been shown in Fig. 4 C. SDF-1 (100 ng/ml) significantly increased hERG tail currents."
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