IndraLab

Statements

SATB1 binds USP47. 13 / 13
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"Together with our findings that SATB1 interacted with USP47, these results indicate that deubiquitinase activity is required for USP47 to remove ubiquitin from SATB1."
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"SATB1 expression promoted tumor cell glycolysis and glutamine metabolism, while USP47 protein bound to and deubiquitinated SATB1 to increase its intracellular levels, thus promoting glycolysis and glutamine metabolism."
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"To explore the roles of USP47-SATB1 interactions in CRC metastasis, we examined cell migration and invasion."
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"As seen in Fig. 2 E, this mutant failed to inhibit the ubiquitination of SATB1 protein without affecting USP47 interaction with SATB1 ( Fig. 2 Eand F)."
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No evidence text available
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"USP47 interacted with SATB1 through its catalytic core domain and antagonized Smurf2-mediated SATB1 degradation."
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No evidence text available
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No evidence text available
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"Here, we demonstrate that USP47 interacts with SATB1 to mediate its ubiquitination and positively regulate its stability."
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"To further confirm that the interaction between SATB1 and USP47 is specific, we transfected these alone or together into 293T cells and evaluated their interaction by immunoprecipitation and western b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To further confirm that the interaction between SATB1 and USP47 is specific, we transfected these alone or together into 293T cells and evaluated their interaction by immunoprecipitation and western b[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In a normal state, USP47 binds to E-cadherin, preventing its degradation; however, when cells are under hypoxic conditions or during EMT, the binding of USP47 to Snail and SATB1 is enhanced, thereby inhibiting the expression of E-cadherin."
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"In addition, we examined whether endogenous SATB1 interacted with USP47 in HCT116 cells."
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