IndraLab

Statements

USP13 activates autophagy. 19 / 19
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"Spautin-1 inhibits autophagy by reducing the activity of USP10 and USP13, which promotes a major aspect of autophagy: degradation by Vps34 complexes."
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"Our data showed that USP13 knockdown inhibited autophagy , which is consistent with the previous report that USP13 promotes autophagy through deubiquitinating BECN1 to stabilize the protein ( Liu et al ., 2011 ) ."
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"USP13 also promotes the expression of autophagy-related proteins by interacting with the Vps34 complex (37,40,41).4."
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"Moreover, USP13 promoted autophagy in AML cells."
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"USP13 stabilizes the beclin1 subunit of Vps34-beclin1 and promote autophagy."
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"USP13 promotes acute myeloid leukemia cell proliferation and autophagy by promoting ATG5."
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"USP13 promotes AML cell growth and autophagy by upregulating ATG5."
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"A recent study showed that inhibition of USP13 reduced autophagy and ROS accumulation, and attenuated pyroptosis."
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"However, these effects were greatly blocked by USP13 overexpression which causes increases in autophagy as well as ferroptosis [21]."
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"In all, these results indicated that USP13 promoted autophagy dependent on METTL3 in OS cells (Fig. 7)."
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"In gastrointestinal mesenchymal tumors, inhibitors of USP13 attenuate ATG5 and inhibit m6A modification-mediated autophagy."
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"USP13 stabilizes the Vps34 complex to promote autophagy, and therefore, inhibition of USP13 reduces autophagy."
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"Hence, USP13 inhibition suppressed autophagy [48,49,50]."
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"Therefore , depletion of USP13 promotes cellular apoptosis and impedes autophagy ."
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"Previous studies reported an oncogenic role of ATG5 in the progression of OS20, 21, so it is reasonable to conclude that the USP13/METTL3 cascade promotes OS progression by targeting oncogenic autophagy."
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"USP13 also promotes autophagy by deubiquitinating VPS34 (Xie et al., 2020)."
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"Collectively, our study results indicate that USP13 promotes glycolysis and tumor progression in OS by stabilizing METTL3, thereby stabilizing ATG5 mRNA and facilitating autophagy in OS."
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"USP13 stabilizes the Vps34 complex to promote autophagy , and therefore , inhibition of USP13 reduces autophagy ."
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"USP13 activates mitochondrial energy metabolism, autophagy, DNA damage response, glutaminolysis, and fatty acid synthesis [73]."
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