IndraLab

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USP22 inhibits Wnt/β-catenin. 3 / 3
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"Down-regulation of USP22 reduces cell stemness and enhances the sensitivity of pancreatic cancer cells to cisplatin by inactivating the Wnt/β-catenin pathway."

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"Inhibition of USP22 reduced the cell stemness and augmented the sensitivity of PC cells to cisplatin by inhibiting the Wnt/β-catenin pathway."

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"It has also been shown that micro RNA-30-5p attenuated the stemness and chemoresistance of CRC stem cells via attenuating the expression of USP22 and suppressing the Wnt/β-catenin signaling [42] ."