IndraLab

Statements

USP18 inhibits SAMHD1. 3 / 3
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"USP18 downregulates p21 by accumulating misfolded dominant negative p53, which inactivates wild-type p53 transactivation, leading to the upregulation of key enzymes involved in de novo dNTP biosynthesis pathways and inactivated SAMHD1."
38675828
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"Immune regulatory components whose downregulation improves anti-HIV responses include activated leukocyte cell adhesion molecular (ALCAM) , ubiquitin-specific proteinase 18 (USP18) which negatively regulates type I interferon responses and SAMHD1 in macrophages , and miR-146a that represses antiviral cytokine signaling ."
34985679
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"In the first experiments on USP18 and HIV-1, we observed that USP18 expression could prevent SAMHD1’s restriction to HIV-1."
38675828