IndraLab

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NGF activates SCN10A. 9 / 9
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"While infusion of exogenous NGF to the transected nerve restores SNS and PN3 transcripts to near-normal levels in small DRG neurons, TTX-R sodium currents are only partially rescued."
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"There are also other mechanisms: NGF up-regulates a number of genes (substance-P, Nav1.8, BDNF) in nociceptive neurons that further sensitize these neurons and facilitate the activation of second-orde[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"While infusion of exogenous NGF to the transected nerve restores SNS and PN3 transcripts to near-normal levels in small DRG neurons, TTX-R sodium currents are only partially rescued."
10216225
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"We also observed the previously described NGF-induced increase in Nav1.8 amplitudes in small diameter IB4 /caps neurons, though in our hands, this effect was not statistically significant, which may be attributed to the rather small samples size of these cells in our study (Figure 6(e) and (f))."
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"NGF can be released upon tissue inflammation and is implicated in chronic pain.47 NGF sensitizes nociceptors and promotes their excitability by up-regulating TRPV1 and Nav1.8 channel expression and activity via acting on the TrkA receptor.48,49 In a previous study, Cheng et al4 found that TNF-α produced from ipsilateral injured DRG of a rat spinal nerve ligation model can diffuse to the contralateral side via cerebrospinal fluid and activates satellite cells to produce NGF, which promotes nociceptor excitability on the contralateral side and induces MIP."
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"Significance:. NGF mediates the Na + channel plasticity with a shift from TTX-resistant Nav1.8 to TTX-sensitive Nav1.7 in bladder afferent neurons, which could be a possible underlying mechanism of bladder afferent hyperexcitability and detrusor overactivity after SCI."
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"This is probably related to the known inflammation-induced nerve growth factor (NGF)-dependent upregulation of Nav1.7 and Nav1.8 in nociceptors, and to their upregulation and increased Na current density in L4 DRG neurons after L5 SNL/SNA [13,32,59,80]."
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"A transcript with a repeat of exon 3 is profoundly up-regulated by nerve growth factor (NGF), raising the possibility of functional differences in Nav1.8 channels expressed in inflammatory and neuropa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, NGF acts via TrkA and p75 to activate a number of other kinase pathways, for example, that of p38 kinase, leading to altered gene transcription and increased synthesis of sensory neuropeptides (substance P, CGRP), ion channels (TRPV1, NaV1.8, ASIC3) [141-143], membrane receptors such as bradykinin and P2X3 [144,145], and structural molecules, including neurofilament and channel anchoring proteins such as the annexin light chain p11 [121]."
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