IndraLab

Statements

USP7 inhibits USP7. 5 / 7
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"Importantly, we demonstrated that USP7 knockdown or inhibition of USP7 with its inhibitors P5091 and P22077 could repress the growth of lung cancer cells in vitro."
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"ROS assay showed that H 2 O 2 elevated ROS production which was abolished by USP7 KD or USP7 inhibition ( xref )."
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"S/P fractionation showed that overexpression of Atx7 -N172-IRF/3IRF in A549 cells significantly decreased the USP7 level in supernatant, whereas it remarkably increased the accumulation of USP7 in pellet (Figure 2B)."
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"Further analyses of the young adult cortex showed that loss of USP7 was restricted in NeuN-positive cortical neurons of Usp7 cKO mice (Figure 1B)."
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"Upregulation of FTO expression reduced the m6A level of ubiquitin-specific peptidase 7 (USP7), increased the USP7 mRNA stability, and promoted the development of NSCLC (102)."
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