IndraLab

Statements

PRPF8 activates cilium assembly. 3 / 3
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"These data suggest that PRPF8 regulates CP110 removal and further promotes ciliogenesis, depending on its ability to bind to the linear ubiquitin chains."
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"Strikingly, depletion of PRPF8 in RPE-1 cells dramatically suppressed CP110 removal from the mother centrioles after serum starvation and significantly inhibited ciliogenesis (Fig. 5, C–E; and Fig. S5 C)."
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"PRPF8 promotes CP110 removal to initiate ciliogenesis by binding to the linear ubiquitin chains."
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