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ME1 binds USP19. 12 / 12
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"Next, we studied whether ERK2 affected the interaction between ME1 and USP19."
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"IP results showed that EGF treatment dramatically enhanced USP19-ME1 interaction in NCM460 cells ( Figure S2 R)."
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"The endogenous interactions between USP19 and ME1 were confirmed by co-IP experiments in CRC HCT116 and LoVo cells ( Figures 1 B and S1 B)."
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"Next, we studied whether ERK2 affected the interaction between ME1 and USP19."
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"These results are consistent with the proteomic and biochemical findings, discussed above, and support the idea that the USP19-ME1 axis mediates lipogenesis and plays a critical role in both murine an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, the authors showed that the USP19-ME1 signaling axis is dysregulated in human colorectal cancer samples, and that USP19 is upregulated during colorectal carcinogenesis pathogenesis and spontaneous tumor development."
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"The endogenous interactions between USP19 and ME1 were confirmed by co-IP experiments in CRC HCT116 and LoVo cells ( Figures 1 B and S1 B)."
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"Together, these findings indicate that USP19 interacts with ME1 in CRC cells."
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"Thus, the USP19-ME1 axis plays a crucial role in colorectal carcinogenesis [ xref ]."
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