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USP19 deubiquitinates MGMT. 3 / 3
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"Mechanistically, USP19 binds to MGMT and then deubiquitinates MGMT, causing the removal of ubiquitin chains, which stabilize MGMT."
38644551
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"To further investigate the mechanism of binding between USP19 and MGMT, we found that the N terminal (1‐596aa) and UI domain of USP19 were responsible for binding with MGMT (Figure 2C).2.3 USP19 deubiquitinates MGMT in vivo and in vitro."
38644551
reach
"To further clarify the effect of USP19‐mediated MGMT stabilization, we assessed whether USP19 deubiquitinated MGMT in cells."
38644551