IndraLab

Statements

KCNA3 binds kcsA and ion channel. 2 / 2
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"The control fiber tip was dipped in 86 nM ShK and no response was observed ( xref ), which confirms that the oscillation amplitude change shown in xref was due to the specific binding of ShK to the KcsA-Kv1.3 ion channel proteins."
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"To examine the capability of the Nano-oscillator platform for measuring small molecule binding kinetics and demonstrate its potential application in drug screening, we studied the binding of a small molecule drug candidate 1 (4-(2-ethylpiperidin-1-yl)-2-methyl-6-phenyl-5H-pyrrolo[3,2-d] pyrimidine, MW = 320 Da) to a chimeric ion channel protein KcsA-Kv1.3 ( xref ), which plays an important role in autoimmune diseases. xref To stabilize the membrane protein in aqueous solution, KcsA-Kv1.3 was encapsulated in a Nanodisc consisting of a nano-scale lipid bilayer disc fastened by a membrane scaffold protein."
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