IndraLab

Statements

EIF3F decreases the amount of PHGDH. 2 / 2
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"In addition, eIF3f KD accelerates PHGDH protein turnover (Figure 2F), and leads to increased poly‐ubiquitination level of PHGDH (Figure 2G), while ectopic‐expression of eIF3f leads to increased steady‐state expression of PHGDH (Figure 2H) and reduced poly‐ubiquitination level of PHGDH in a dose‐dependent manner (Figure 2I)."
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"Immunohistochemistry and immunoblotting showed that tumors with eIF3f KD exhibited a marked reduction in proliferation marker Ki‐67 and reduced the PHGDH, PSPH, PSAT1, and MYC expression (Figure 5E)."
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