IndraLab

Statements

USP22 activates Neoplastic Stem Cells. 4 / 4
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"Additionally, USP22 promotes CSC maintenance through the Wnt/β-catenin pathway (81)."
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"Interestingly, we identified that USP22 promotes CSC properties and drug tolerance by supporting the oxidative phosphorylation program, known to be largely responsible for the poor response to conventional therapies in this particularly aggressive BC subtype."
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"In addition, USP22 promotes CSC maintenance through the Wnt/β-catenin pathway (37)."
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"In this study, we demonstrated that USP22 mediated protein stabilization of BMI1 promotes gastric CSC stemness maintenance and GC progression, thereby providing a rationale for USP22 targeting as a potential therapeutic approach against GC."
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