IndraLab

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TSPY1 inhibits USP7. 3 / 3
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"With this work, we reveal that TSPY1 suppresses ubiquitin specific peptidase 7 (USP7)-mediated p53 function; the promotion of spermatogonial proliferation by TSPY1 through the p53 signaling pathway probably contributes to human spermatogenesis."

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"These observations suggest that TSPY1 and TSPYL5 can induce USP7 degradation via the 26S proteasome system."

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"TSPY1 induces ubiquitin dependent degradation of USP7."