IndraLab

Statements

USP44 inhibits RNF168. 3 / 3
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"Furthermore, overexpression of USP44 impairs RNF168, 53BP1 and RAP80 foci, all of which can be directed to DSBs by ubiquitinated H2A."
32708614
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"On the other hand, we also found 13 DUBs that were recruited to DNA damage sites but gave only marginal DSB repair defects upon siRNA depletion, including OTUB1, a negative regulator of the UBE2N (UBC13) ubiquitin E2 enzyme 24, USP44 that is reported to antagonize RNF168 dependent ubiquitylation 25, and OTUB2 that functions in repair-pathway choice 26 (XREF_FIG, XREF_FIG, and XREF_FIG), suggesting that some of the additional DUBs we identified might be negative DDR regulators and/or be involved in repair-pathway choice."
25194926
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"Similar to USP26 and USP37, two other DUBs, USP3 and USP44, were shown to reverse RNF168 induced chromatin ubiquitylation, thereby controlling the accumulation of BRCA1 and 53BP1 at sites of DNA damage."
26101254