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ATXN3 activates PNKP. 7 / 11
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"Interestingly, it was shown that wild-type ataxin-3 led to stimulation of PNKP, whereas expanded ataxin-3 led to inhibition XREF_BIBR XREF_BIBR."
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"Our studies described in the accompanying manuscript by Chatterjee et al suggest that PNKP is a native ATXN3 interacting protein, and that ATXN3 modulates PNKP activity and DNA repair (Chatterjee et al, Figs."
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"XREF_FIG shows that WT ATXN3 stimulated PNKP 's 3 '-phosphatase activity (ln 2 vs. lns 3-7) ~ 4-fold; in contrast, ATXN3-Q72 reproducibly and significantly abrogated PNKP 's activity (~ 3.5-fold, XREF_FIG, ln 2 vs. ln 6; n = 3)."
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"Two studies in 2015 showed that ATXN3 binds to and enhances PNKP 3 '-phosphatase activity, promoting DNA repair."
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"However, how ATXN3 enhances PNKP activity was not clear from these studies."
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"ATXN3 then activates PNKP to generate 3′−OH ends, from which an RNA-dependent DNA polymerase can restore the missing sequence by using the nascent complementary RNA as template."
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"However , how ATXN3 enhances PNKP activity was not clear from these studies ."
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