IndraLab
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Pyraclofos activates KCNB1. 21 / 21
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"The hypothesis that cell-to-cell variation in fluorescence dynamics is due to the inherent variability of Kv2.1 voltage sensor activation could be more definitively tested by identifying whether a correlation exists between theV 1/2 of the QV and fluorescence–voltage relationship from individual cells labeled with GxTX-594."
reach
"They reported that it suppresses the ion current in a concentration-dependent manner with IC50≈ 21 μM and shifts half-maximal voltage toward the higher potentials.The authors of the article [37] found that, similarly as in the case of Kv1.5 channels, quercetin can prevent the inhibition of the Kv2.1 currents in the pulmonary artery smooth muscle cells (PASMC) of rats pretreated with the monocrotaline.In [40], the authors studied the impact of licorice and isoliquiritigenin on IKur mediated by Kv2.1 expressed in H9c2 cells derived from rat cardiac myoblasts."
sparser
"As expected, voltage activation of rat Kv2.1 channels was required for the onset of RY785 inhibition, but Marquis and Sack found that recovery from inhibition is also voltage dependent: voltage activation of Kv2.1 channels speeds the restoration of K + currents after RY785 washout, whereas channels held at negative membrane potentials barely recover any conductance at all."
reach
"As expected, voltage activation of rat Kv2.1 channels was required for the onset of RY785 inhibition, but Marquis and Sack found that recovery from inhibition is also voltage dependent: voltage activation of Kv2.1 channels speeds the restoration of K currents after RY785 washout, whereas channels held at negative membrane potentials barely recover any conductance at all.The simplest explanation for these observations is that voltage activation induces a conformational change in Kv2 channels that allows RY785 to access its binding site within the channel."