IndraLab

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Pyraclofos activates KCNB1. 7 / 7
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"Voltage activation of Kv2.1 channel exhibited a sigmoidal time course 22 (Figure  3a), where there was an initial delay in macroscopic current upon depolarization (marked by red arrow)."
33101845
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"Voltage-activated Kv2.1 channels have properties commensurate with a contribution to delayed rectifier currents and are expressed in neurones throughout the mammalian central nervous system."
14608003
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"We conclude that AMIGO1 modulates the Kv2.1 conductance activation pathway by destabilizing the earliest resting state of the voltage sensors."
35314141
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"We find that voltage activation of Kv2.1 channels triggers GxTX dissociation, and thus GxTX binding dynamically marks Kv2 activation."
25331865
sparser
"We use voltage clamp spectroscopy (VCS) to collect full emission spectra of JP-GxTX conjugates as a function of membrane potential and find that they vary with labeling site on the toxin, the presence of Kv2 channels, and in response to Kv2.1 voltage activation."
32579336
sparser
"Furthermore, it was reported that coexpression of stx1A reduced the surface expression of the voltage-activated potassium channel Kv2.1 ( xref ) but increased the surface expression of Kv1.1 ( xref )."
24743596
sparser
"The voltage-activated K(+) channel subunit Kv2.1 can form heterotetramers with members of the Kv6 subfamily, generating channels with biophysical properties different from homomeric Kv2.1 channels."
19074135