IndraLab

Statements

KCNH2 binds NEDD4. 8 / 8
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"Disrupting the Nedd4-2 interaction with hERG eliminates the effects of Cav-3 on hERG channels."
32387251
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"As shown in Fig. 3 C, a specific signal for Nedd4-2 was found when ERG1 was immunoprecipitated, thus indicating an interaction between ERG1 and Nedd4-2 in the guinea pig heart."
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"Whether the CAV3-V37L mutation leads to an enhancement in hERG-Nedd4-2 interaction remains unknown."
32387251
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"To confirm the down-regulation of the functional form of hERG1 by Nedd4-2, we quantified the amount of hERG1 localized at the plasma membrane by cell surface biotinylation assays."
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"The biochemical interactions between hERG1 and Nedd4-2 were investigated by co-immunoprecipitation experiments ( Fig. 3 )."
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"Expression of Cav-3 enhances the hERG-Nedd4-2 interaction, leading to an increased ubiquitination and degradation of hERG channels on the cell surface membrane."
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"It is possible that several PY motifs of hERG1 interact with several WW domains of Nedd4-2 simultaneously.We also demonstrated that WWP2, but not Nedd4-1, interacts with hERG1."
21463633
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"Here, we provide evidence of an interaction between hERG1 and Nedd4-2 in guinea pig hearts, suggesting that ubiquitylation of the channel by this ubiquitin ligase could play a role in its regulation [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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