IndraLab
Statements
KCNMA1 activates bradykinin. 23 / 23
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"XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR On the other hand, well established (such as NS1608, NS8 and NS1619) and novel (such as NS11021) BK channel openers increase BK channel open probability and whole-cell BK currents, causing DSM hyperpolarization and relaxation in various species."
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"Taking these data together, the changes in BK current establish that the N999S mutation confers GOF properties to a brain expressed BK channel variant, producing larger BK currents that activate at lower voltages because of the shifted V 1/2 and activate faster and deactivate slower than WT."