IndraLab

Statements

OTUB2 activates NFkappaB. 4 / 5
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"Since OTUB2 can promote cancer progression by regulating Hippo, NF-kB and Akt/mTOR pathways , we next investigated the effects of OTUB2-IN-1 on regulating Hippo, NF-κB and Akt/mTOR pathways."
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"Mechanistically, OTUB2 overexpression can activate NF-kappaB signaling mostly by stabilizing TRAF6."
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"Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling."
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"Our further investigations revealed that knockdown of OTUB2 significantly suppressed NF-kappaB-driving luciferase activity, and markedly inhibited the phosphorylation of NF-kappaB p65 in liver cancer cells, which indicated that OTUB2 mediated liver cancer cell growth by regulating NF-kappaB signaling."
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