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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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OTUB2 activates NFkappaB. 3 / 4

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"Mechanistically, OTUB2 overexpression can activate NF-kappaB signaling mostly by stabilizing TRAF6."

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"Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-kappaB signaling."

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"Our further investigations revealed that knockdown of OTUB2 significantly suppressed NF-kappaB-driving luciferase activity, and markedly inhibited the phosphorylation of NF-kappaB p65 in liver cancer cells, which indicated that OTUB2 mediated liver cancer cell growth by regulating NF-kappaB signaling."

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OTUB2 activates NFkappaB. 3 / 4

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