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COPS6 binds MDM2. 2 / 2

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"Similarly, overexpression of COPS6 binds to MDM2, and prevents the process of its auto-ubiquitination and degradation, which leads to the accumulation of MDM2 and decrease of p53 in breast cancer (49)."

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"CSN6 makes a contribution to the binding of CSN and E3 ligases [9,10] , and directly binds to MDM2, which is an ubiquitin ligases correlated with p53 pathway [11] ."

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IndraLab

Statements

COPS6 binds MDM2. 2 / 2

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