IndraLab

Statements

Reactive oxygen species inhibits USP7. 3 / 3
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"Importantly, this in vitro ROS-induced inhibition of USP7 is also fully reversible by DTT ( xref )."
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"In this way, FOXO4-stimulated DNA damage response is likely moderated unless ROS levels are high enough to inhibit USP7, triggering hyperactivation of FOXO4 (231, 232)."
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"In agreement with their endogenous counterparts, ectopically expressed Flag-USP7 could be inhibited by ROS, while Flag-USP28 was more refractory to this inhibition ( xref )."
23219552