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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Reactive oxygen species inhibits USP7. 3 / 3

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"Importantly, this in vitro ROS-induced inhibition of USP7 is also fully reversible by DTT ( xref )."

23219552

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"In this way, FOXO4-stimulated DNA damage response is likely moderated unless ROS levels are high enough to inhibit USP7, triggering hyperactivation of FOXO4 (231, 232)."

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"In agreement with their endogenous counterparts, ectopically expressed Flag-USP7 could be inhibited by ROS, while Flag-USP28 was more refractory to this inhibition ( xref )."

23219552

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...