IndraLab

Statements

NEDD4L inhibits KCNH2. 8 / 8
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"The major findings of this study are as follows : 1) hERG1 interacts via its PY motif with the ubiquitin ligase Nedd4-2, 2) this interaction promotes the down-regulation of the functional form of the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overexpression of Nedd4-2 in heterologous HEK293 cells downregulates hERG expression in the plasma membrane and thus decreases hERG currents via enhancing hERG ubiquitination (Guo et al., 2012)."
36059970
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"Although both immature and mature hERG channels contain the PY motif, Nedd4-2 selectively mediates the degradation of mature hERG channels."
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"Our results show that the ubiquitin ligase Nedd4-2 down-regulates I hERG1 measured in a mammalian cell line."
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"We previously showed that the E3 ubiquitin ligase Nedd4-2 mediates degradation of hERG channels."
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"The increase in hERG protein was associated with PKC induced phosphorylation (inhibition) of Nedd4-2, an E3 ubiquitin ligase that mediates hERG degradation."
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"These data indicated that overexpression of Nedd4-2 significantly increased the degradation of mature hERG protein."
36059970
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"We have previously shown that mature hERG channels are degraded by ubiquitin ligase Nedd4-2 via enhanced channel ubiquitination."
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