IndraLab

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NEDD4L inhibits KCNH2. 6 / 6
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"We previously showed that the E3 ubiquitin ligase Nedd4-2 mediates degradation of hERG channels."
24688054
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"Our results show that the ubiquitin ligase Nedd4-2 down-regulates I hERG1 measured in a mammalian cell line."
21463633
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"We have previously shown that mature hERG channels are degraded by ubiquitin ligase Nedd4-2 via enhanced channel ubiquitination."
23589291
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"The major findings of this study are as follows : 1) hERG1 interacts via its PY motif with the ubiquitin ligase Nedd4-2, 2) this interaction promotes the down-regulation of the functional form of the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21463633
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"The increase in hERG protein was associated with PKC induced phosphorylation (inhibition) of Nedd4-2, an E3 ubiquitin ligase that mediates hERG degradation."
31015282
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"Although both immature and mature hERG channels contain the PY motif, Nedd4-2 selectively mediates the degradation of mature hERG channels."
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