IndraLab

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UCHL3 activates Ubiquitin. 2 / 2
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"In our study, we found that the ubiquitin–proteasome system (UPS) was modulated by the regulation of some ubiquitin enzyme and ligases genes (uchl3, trim 25, trim39, ubr7 and ube2i) and proteasome subunits (psma4, psma6, psmb10, psmc2 and rad23a), which act as protein binding signalling and protein degradation, respectively."
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"The relevant control exerted by these DUBs on ubiquitin homeostasis may account for these effects since pharmacological blocking of UCHL1 or UCHL3 reduced the monomeric ubiquitin pool, in turn restricting the ubiquitination of GlyT2 in neurons (XREF_FIG)."
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