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Dimethyl sulfide inhibits NLRP3. 6 / 6
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"To confirm whether or not MSM and DMSO inhibit NLRP3 inflammasome activation via mitochondrial ROS generation, we firstly confirmed the effect of DPI, an inhibitor of cytosolic and mitochondrial ROS p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, LPS combined with Nigericin was applied to stimulate the cells to activate the NLRP3 inflammasome, ELISA, WB, and qRT-PCR results showed that MSM potently blocked the activation of the NL[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, MSM as well as DMSO inhibited NLRP3 inflammasome activation by blocking mitochondrial ROS generation.In this study, we confirmed MSM as a selective NLRP3 inflammasome inhibitor."
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"We further confirmed that MSM attenuated NLRP3 inflammasome activation through inhibition of mitochondrial ROS production, similar to DMSO."
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"Thus, MSM not only blocked the NLRP3 inflammasome at the activation step but also down-regulated pro-IL-1beta and NLRP3 expression at the priming step.MSM is a form of organic nutritional sulfur found[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"MSM inhibits the ROS/NLRP3 inflammasome signaling pathway by enhancing Nrf2/HO-1 to treat MSU-induced gouty arthritis ( Fig. 11 )."
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