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Dimethyl sulfide inhibits NLRP3. 5 / 5
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"To confirm whether or not MSM and DMSO inhibit NLRP3 inflammasome activation via mitochondrial ROS generation, we firstly confirmed the effect of DPI, an inhibitor of cytosolic and mitochondrial ROS p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In our results, MSM significantly attenuated NLRP3 inflammasome activation in lipopolysaccharide primed macrophages, although it had no effect on NLCR4 or AIM2 inflammasome activation."
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"Thus, MSM as well as DMSO inhibited NLRP3 inflammasome activation by blocking mitochondrial ROS generation.In this study, we confirmed MSM as a selective NLRP3 inflammasome inhibitor."
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"We further confirmed that MSM attenuated NLRP3 inflammasome activation through inhibition of mitochondrial ROS production, similar to DMSO."
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"Thus, MSM not only blocked the NLRP3 inflammasome at the activation step but also down-regulated pro-IL-1beta and NLRP3 expression at the priming step.MSM is a form of organic nutritional sulfur found[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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