IndraLab

Statements

USP3 activates Stomach Neoplasms. 9 / 9
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"49 Their findings indicate that USP3 overexpression accelerates GC cell proliferation by promoting G1–S transition and upregulating cyclins D and E."
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"Silencing of USP3 suppressed GC cell proliferation and spreading in vitro as well as xenograft proliferation and metastasis in vivo; however, opposite results were obtained when USP3 was overexpressed."
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"Additionally, USP3 promotes GC cell migration and invasion by positively regulating the EMT process."
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"However, it is unknown whether these three proteins are involved in the USP3-directed proliferation of GC cells, and future studies should examine their oncogenic roles in GC."
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"These data suggest that USP3 promotes GC progression and metastasis by deubiquitinating COL9A3 and COL6A5 ."
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"52 Overall, USP3 primarily functions as a tumor promoter in GC, driving GC cell proliferation, invasion, migration, and the EMT process.Ubiquitin‐specific protease 3 has also been implicated in esophageal squamous cell carcinoma (ESCC)."
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"Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3 ."
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"USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3 / COL6A5 stabilisation ."
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"According to the literature review, USP3 promotes GC cell migration and invasion [20]; SLC7A6 hasn’t been reported in studies related to cancer; IGF2BP1 accelerates GC progression [21]; and TKT facilitates breast cancer metastasis [22]."
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