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USP45 activates V-ATPase. 2 / 2

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"We then investigated whether USP45 could modulate the localization of V-ATPase on endolysosomes."

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"Interestingly, the ablation of USP45 significantly enhanced the localization of the V-ATPase V0 subunit d (ATP6V0D) at late endosomes (Rab 7) and lysosomes (LAMP2), while having no effects on its localization at early endosomes (EEA1) (Fig. 4, E and F)."

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USP45 activates V-ATPase. 2 / 2

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