IndraLab

Statements

USP38 binds STRAP. 3 / 3
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"Notably, treatment of HL-1 cells with indoxyl sulfate (IS), a representative uremic toxin, significantly enhanced the interaction between USP38 and STRAP, as evidenced by increased Co-IP intensity (Supplementary Figure xref ), suggesting that pathological stimuli strengthen this interaction."
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"Molecular docking analysis predicted a strong interaction between USP38 and STRAP (binding energy: −15.9 kcal/mol; Fig. xref A)."
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"Subsequent co-immunoprecipitation (Co-IP) experiments conducted in both atrial tissue and HEK-293 T cell lysates transfected with the relevant plasmids confirmed the endogenous and exogenous interaction between USP38 and STRAP (Fig. xref D-G)."
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