IndraLab

Statements

Calcium(2+) activates ATXN3. 9 / 9
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"Administration of an activator of calcium activated potassium channels, SKA-31, partially corrects abnormal Purkinje cell firing and improves motor function in SCA3 mice."
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"Interestingly, it was shown that inhibition of calcium-dependent protease calpain suppressed the aggregation of the pathological ataxin-3 in cells and prevented neurodegeneration [35,36]."
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells."
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"Most of these findings parallel our previous studies of Ca 2+ signaling in HD and SCA3 mouse models and indicate that deranged Ca 2+ signaling contributes to pathogenesis of at least these three polyglutamine-expansion disorders."
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"The authors hypothesized that calcium dependent activation of proteases causes the cleavage of ATXN3 leading to protein aggregation as a result."
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"In addition, ASO-mediated reduction of ATXN3 corrects underlying changes in KV channel expression and improves the physiology of Purkinje neurons, which is improved after short-term administration of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous studies have indicated that this deregulation in Ca 2+ signaling in SCA3 is through various channels such as RYR and Insp3R1 ( Chen et al., 2008 )."
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
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