IndraLab

Statements

Calcium(2+) activates ATXN3. 6 / 6
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
26023252
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells [XREF_BIBR]."
21210219
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"The authors hypothesized that calcium dependent activation of proteases causes the cleavage of ATXN3 leading to protein aggregation as a result."
23651546
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"Most of these findings parallel our previous studies of Ca 2+ signaling in HD and SCA3 mouse models and indicate that deranged Ca 2+ signaling contributes to pathogenesis of at least these three polyglutamine-expansion disorders."
19625506
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"It was discovered that inhibition of Ca 2+ -dependent protease calpain suppressed aggregation of polyglutamine expanded Atxn3 in transfected cells."
22353486
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"Administration of an activator of calcium activated potassium channels, SKA-31, partially corrects abnormal Purkinje cell firing and improves motor function in SCA3 mice."
21900579