IndraLab

Statements

USP8 deubiquitinates CD274. 6 / 6
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"USP8 depletion enhanced immunotherapy by regulation of TME via targeting PD-L1 ubiquitination and activating the infiltrated CD8+ T cells (79)."
36733484
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"For instance, USP8, upregulated in pancreatic cancer, can deubiquitinate PD-L1."
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"In line with this report, USP8 deubiquitinated PD-L1 and upregulated its expression in pancreatic cancer."
36733484
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"On the one hand, USP8 deubiquitinates PD-L1 in PDAC, while combined treatment with a USP8 inhibitor and an anti-PD-L1 antibody enhances the infiltration of IFN-γ TNF-α CD8 T cells and effectively suppresses liver metastasis by increasing antitumor immunogenicity [21]."
38715050
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"Moreover, USP9X, USP8, and CSN5 can deubiquitinate PD-L1, and OTUB1 increase PD-L1 levels by preventing new synthetic PD-L1 from entering the ERAD."
38715050
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"On one hand, pancreatic cancer tissues presented obviously higher USP8 levels and USP8 promoted the deubiquitination of PD-L1 protein."
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