IndraLab

Statements

OTUB2 increases the amount of RIPK3. 3 / 3
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"Consistently, overexpression of OTUB2 increased RIPK3 protein levels but did not change RIPK1 expression (Fig. 4E; Appendix Fig. S6D)."
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"Importantly, OTUB2 deletion reduced RIPK3 protein levels in HT22 cells (Fig. 3P), consolidating the in vivo findings (Fig. 3A)."
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"Although OTUB2 deletion significantly reduced RIPK3 protein levels in HT22 cells (Fig. 4A,B), OTUB2 deficiency did not change the transcription of Ripk3 mRNA (Fig. 4C), indicating that OTUB2 regulates RIPK3 at post-translational levels."
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