IndraLab

Statements

COPS6 is phosphorylated. 16 / 16
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rlimsp
"PI3K/Akt inhibitor L294002 reduced the S60 phosphorylation level of CSN6 and caused subsequent E6AP downregulation (Figure 6B)."
26318036
rlimsp
"In addition, phosphorylation of CSN6 increases the stability of CSN6, thereby promoting its regulatory capacity."
30961513
sparser
"In addition, phosphorylation of CSN6 increases the stability of CSN6, thereby promoting its regulatory capacity."
30961513
reach
"These data imply that CSN6 possibly regulates the gene expression of SGOC genes and impacts SGOC amino acid metabolism through its negative impact on FOXO4 that transcriptionally suppresses the gene expression of SGOC genes.2.6 PKB/Akt-Mediated CSN6 Phosphorylation Enhances COP1-Regulated FOXO4 Ubiquitination and Subsequent Elevation of SGOC Genes."
33101846
sparser
"To determine whether the PKB/Akt‐mediated CSN6 phosphorylation affects FOXO4 stability, we examined the steady‐state expression of FOXO4 and COP1 in the presence of CSN6S60A, a construct with no PKB/Akt phosphorylation site."
33101846
sparser
"Treatment with calf intestinal alkaline phosphatase (CIP) reduced the EGF-induced steady-state expression of CSN6, indicating that CSN6 phosphorylation is required in this process ( xref ) and presumably acts through ERK."
26267535
sparser
"To confirm the existence of an ERK-specific phosphorylation site in CSN6 in vivo, we used an anti–phospho-serine antibody to detect the increase of serine-phosphorylated CSN6 in EGF-treated cells ( xref )."
26267535
sparser
"MEK1 inhibition with PD98059 treatment abolished the serine phosphorylation of CSN6 ( xref )."
26267535
sparser
"These results indicate that PKB/Akt‐mediated CSN6 phosphorylation is critical in stabilizing COP1, thereby enhancing ubiquitination level of FOXO4."
33101846
sparser
"Together, these results indicate that EGF/ERK mediated CSN6 phosphorylation and diminished CSN6 ubiquitination and turnover."
26267535
rlimsp
"Furthermore, we found that EGF treatment increased the S60 phosphorylation level of CSN6 (Figure 6B) with concurrent Akt phosphorylation."
26318036
sparser
"The authors further showed that Akt-mediated phosphorylation and stabilization of CSN6 contributed to p57 Kip2 degradation."
23470457
rlimsp
"The protein expression levels of Akt, phosphorylated (p-)Akt, CSN6, Myc, Bax, Bcl-2, caspase-3 cleaved caspase-3 and p53 in HT-29 cells were determined using western blotting."
27748879
sparser
"PKB/Akt‐Mediated CSN6 Phosphorylation Enhances COP1‐Regulated FOXO4 Ubiquitination and Subsequent Elevation of SGOC Genes."
33101846
sparser
"Further investigations to understand the effects of CSN6 phosphorylation on tumorigenesis and COP9 function should also be performed."
23099920
rlimsp
"ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development."
26267535