IndraLab

Statements

BAP1 activates FOXO3. 4 / 4
| 4
reach
"These results suggested that BAP1 can mediate SLC7A11 inhibition and neuronal ferroptosis by regulating H2Aub.3.3 FOXO3a regulated BAP1 expression at the transcriptional level."
40080966
reach
"This indicated that the increase in BAP1 after SAH could significantly reduce the degradation of FOXO3a protein for increasing the stability of FOXO3a protein, and inhibiting BAP1 can promote the degradation of FOXO3a protein."
40080966
reach
"Furthermore, BAP1 protein appears to inhibit FOXO3a degradation via the proteasome-dependent pathway, thereby preserving the activity and stability of the FOXO3a protein."
40080966
reach
"These results indicated that FOXO3a was activated in hemin-treated HT22 cells, and silencing FOXO3a effectively inhibited the expression of BAP1 and increased the expression level of SLC7A11.3.5 Overexpressed FOXO3a aggravated neuronal ferroptosis after treatment with hemin."
40080966