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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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3',5'-cyclic AMP inhibits HCN1. 3 / 3

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"Here we have addressed the mechanism of this dual regulation for HCN2 channels, which activate with slow kinetics that are strongly accelerated by cAMP, and HCN1 channels, which activate with rapid kinetics that are weakly enhanced by cAMP."

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"Cyclic nucleotides and their precursors are examples of such agents; thus, for example, reduced cAMP or cGMP concentration in the inner segment could lower the resting HCN1 conductance by an allosteric mechanism (e.g., Eq."

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"In accord, increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively."

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3',5'-cyclic AMP inhibits HCN1. 3 / 3

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