IndraLab

Statements

Dihydroartemisinin inhibits CASP1. 6 / 6
| 6
reach
"There is minimal data on mechanisms by which n-3 PUFA interact with the NLRP3 inflammasome in adipose, though one study in murine 3T3-L1 adipocytes suggested that inhibition of IL-18, IL-1β, and caspase-1 by DHA and EPA were predominantly dependent upon adiponectin, as they were largely attenuated by use of an adiponectin-neutralizing antibody [35]."
30788452
reach
"DHA inhibited caspase-1 cleavage and IL-1β production started by all surveyed agonists, such as MSU, Alum, R837, and ATP, alike to nigericin [86]."
34024569
reach
"Here, we demonstrate that DHA inhibits 5-FU-induced IL-1beta secretion and caspase-1 activity in a MDSC cell line (MSC-2)."
31217433
reach
"In contrast to ceramides, other lipid species, especially DHA and DHA-derived oxylipins, are known to inhibit caspase-1."
32758686
reach
"Western blot analysis showed that p38 inhibitor BIRB796 blocked DHA-induced caspase-1 upregulation whereas inhibitors to Akt and mTROC1 were unable to interfere with DHA-led caspase-1 surge (Figure 8C)."
38058301
reach
"DHA inhibits caspase-1 activity and IL-1beta maturation."
22515414