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OTUB1 activates autophagy. 3 / 3
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"In summary, our findings indicate a causative role of OTUB1 in ferroptosis inhibition, suggesting that the absence of OTUB1 activates autophagy-dependent ferroptosis in skeletal muscle that induces significant muscle loss and weakness."
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"In this context, OTUB1 might be a potential target for new therapies of OSCC.As a key and star deubiquitinating enzyme, OTUB1 mediates ferroptosis, immunity, apoptosis, and autophagy in tumor and non-[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistent with these observations, OTUB1 overexpression induces autophagy while its knockdown represses autophagy induction [XREF_BIBR]."
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