IndraLab

Statements

USP13 activates glioblastoma multiforme cancer stem cell. 4 / 4
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"In vivo bioluminescent analysis confirmed that induced disruption of USP13 by doxycycline treatment significantly inhibited GSC tumor growth in mouse intracranial xenografts (XREF_FIG)."
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"In addition, USP13 disruption significantly reduced GSC proliferation (XREF_FIG) but showed little effects on NSTCs and NPCs (not depicted)."
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"Disrupting USP13 abrogates GSC tumor growth."
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"In addition, IHC staining of Ki-67 and cleaved caspase 3 confirmed that USP13 disruption reduced c-Myc protein in the GSC derived xenografts and led to a significant decrease in cell proliferation and an increase in cell apoptosis within the tumor (not depicted)."
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