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TCHH inhibits COPS5. 3 / 3
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"Thiolutin also inhibits the JAMM metalloproteases Csn5, the deneddylase of the COP9 signalosome, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH), which regulates ubiquitin dependent sorting of cell-surface receptors, and Brcc36, a K63 specific deubiquitnase of BRCC36 containing isopeptidase complex (BRISC) and BRCA1, BRCA2, and containing complex (BRCC)."
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"We found that THL can inhibit Csn5 with an IC 50 of 6.2 muM (XREF_FIG)."
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"We found that THL can inhibit Csn5 with an IC 50 of 6.2 μM ( xref )."
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