IndraLab

Statements

USP19 increases the amount of MARCHF6. 3 / 3
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"In support of this hypothesis, we showed that ABCB11 G238V was stabilized by the USP19 knockdown that reduced MARCH6 expression."
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"Since enzyme activity is generally proportional to the protein expression levels, we expected that knockdown of USP19 would reduce MARCH6 expression, which in turn would stabilize the ABCB11 G238V mut[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we addressed whether knockdown of the endogenous USP19 protein with small interfering RNA (siRNA) would reduce the levels of endogenous MARCH6."
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