IndraLab

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USP10 activates SKP2. 7 / 7
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"Since USP10 is a well characterized DUB in humans, exploring whether USP10 directly regulates the stability of SKP2 protein is attractive."
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"Notably, genetic or pharmacological inhibition of USP10 using Spautin-1 prominently decreased the stability of endogenous SKP2 protein, suggesting that USP10 inhibits the degradation of SKP2 in vivo."
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"WB results presented that knockdown of USP10 impaired the stability of SKP2 protein in BMSCs (Fig. 5D)."
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"Next, we hypothesized that USP10 mediates the posttranslation of Skp2."
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"USP10 stabilizes SKP2 and therefore activates the SKP2/Bcr-Abl signaling pathway, potentially leading to increased proliferation of both imatinib-sensitive and imatinib-resistant CML cells [34]."
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"USP10 modulates the SKP2 and Bcr-Abl axis via stabilizing SKP2 in chronic myeloid leukemia."
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"USP10 functions in cancers by regulating different substrates (androgen receptor, p53, SIRT6, AMPK, and Flt3).145, 146, 147, 148, 149, 150 Liu et al found that primary CML cells overexpressed USP10 and SKP2."
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